منابع مشابه
Red cells shrink during sickling.
Rapid transformatIon of discoid hemoglobin SS erythrocytes into grossly distorted sickled forms suggests alteration of surface/volume ratio. We, therefore, examined the effect of deoxygenation on red cell volume. ‘31llaholed albumin was used as a marker of plasma volume in normal (Hb AA), sickle (Hb SS), and sickle-C (Hb SC) blood. Heparinized blood was incubated for 30 mm at 37#{176}Cin a tpno...
متن کاملRate of Sickling of Red Cells during Deoxygenation of Blood from Persons with Various Sickling Disorders.
By SAMUEL CIIARAcIIE AND C. LOCKARD CONLEY S ICKLED ERYTHROCYTES are rapidly removed for the circulation, an occurrence that accounts for the hemolytic aspects of sickle cell disease.’ Anemia is a usual result but is often asymptomatic and is not the principal cause of the high morbidity and reduced life span of affected persons. Many of the clinical manifestations of sicklemia have been attrib...
متن کاملRED CELLS Dipyridamole inhibits sickling-induced cation fluxes in sickle red blood cells
Sickling-induced cation fluxes contribute to cellular dehydration of sickle red blood cells (SS RBCs), which in turn potentiates sickling. This study examined the inhibition by dipyridamole of the sicklinginduced fluxes of Na1, K1, and Ca11 in vitro. At 2% hematocrit, 10 mM dipyridamole inhibited 65% of the increase in net fluxes of Na1 and K1 produced by deoxygenation of SS RBCs. Sickle-induce...
متن کاملHypoxia-induced in vivo sickling of transgenic mouse red cells.
To develop an animal model for sickle cell anemia, we have created transgenic mice that express a severe naturally occurring human sickling hemoglobin, Hb S Antilles. Due to its low solubility and oxygen affinity, Hb S Antilles has a greater propensity to cause red cell sickling than Hb S. To make transgenic animals that express a high level of Hb S Antilles, the erythroid-specific DNAse I hype...
متن کاملThe Mechanism Aid. Frequency of Sickling . of Red Blood Cells in Deer
Seventy years before siokled red blood cells were seen in the blood of humans they had been noted in blood from members of the Cervidae family. These siokled erythrocytes and their chemistry have been studied in great detail in humans, but very few studies on siokled erythrocytes in Cervidae have been published. In this study, blood samples from 209 mule deer (©docoileus hemionus) from three ar...
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ژورنال
عنوان ژورنال: Blood
سال: 1974
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v44.6.885.885